Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC.

ABSTRACT: Chemodynamic therapy (CDT) based on intracellular Fenton reaction to produce highly cytotoxic reactive oxygen species (ROS) has played an essential role in tumor therapy. However, this therapy still needs to be improved by weakly acidic pH and over-expression of glutathione (GSH) in tumor microenvironment (TEM), which hinders its future application. Herein, we reported a multifunctional bimetallic composite nanoparticle MnO₂@GA-Fe@CAI based on a metal polyphenol network (MPN) structure, which could reduce intracellular pH and endogenous GSH by remodeling tumor microenvironment to improve Fenton activity. MnO₂ nanoparticles were prepared first and MnO₂@GA-Fe nanoparticles with Fe³⁺ as central ion and gallic acid (GA) as surface ligands were prepar

SUBMITTER: Chen W 

PROVIDER: S-EPMC10924346 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature