Causal relationship between immune cells and telomere length: mendelian randomization analysis.

ABSTRACT:

Background

The causal relationship between immune cells and telomere length remains controversial.

Methods

Data on the immune cells were obtained from a previous study with 3,757 participants. Data on telomere length were obtained from the OpenGWAS database. Genome-Wide Association Study (GWAS) data were obtained and screened for eligible instrumental variables (IVs) using the TwoSampleMR package and the Phenoscanner database. To investigate the genetic causality between immune cells and telomere length, Mendelian randomization (MR) analysis and Bayesian weighted Mendelian randomization (BWMR) analysis were used.

Results

MR analysis showed that there is indeed a genetic causal relationship between immune cells and telomere length. A total of 16 immune cells were succe

SUBMITTER: Li Y 

PROVIDER: S-EPMC10924351 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature