Cost-benefit evaluation of advanced therapy lines in metastatic triple-negative breast cancer in Germany.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is responsible for 10-20% cases of breast cancer and is resulting in rising healthcare costs. Thus, health-economic evaluations are needed to relate clinical outcomes and costs of treatment options and to provide recommendations of action from a health-economic perspective.

Methods

We investigated the cost-benefit-ratio of approved treatment options in metastatic TNBC in Germany by applying the efficiency frontier approach. These included sacituzumab-govitecan (SG), eribulin, vinorelbine, and capecitabine. Clinical benefit was measured as (i) median overall survival (mOS) and (ii) health-related quality of life (HRQoL) in terms of time to symptom worsening (TSW). To assess medical benefits, literature was systematically reviewe

SUBMITTER: Wickmann A 

PROVIDER: S-EPMC10924420 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature