Preventing Postoperative Delirium After Major Noncardiac Thoracic Surgery-A Randomized Clinical Trial.

ABSTRACT:

Objectives

To assess the efficacy of haloperidol in reducing postoperative delirium in individuals undergoing thoracic surgery.

Design

Randomized double-blind placebo-controlled trial.

Setting

Surgical intensive care unit (ICU) of tertiary care center.

Participants

Individuals undergoing thoracic surgery (N=135).

Intervention

Low-dose intravenous haloperidol (0.5 mg three times daily for a total of 11 doses) administered postoperatively.

Measurements

The primary outcome was delirium incidence during hospitalization. Secondary outcomes were time to delirium, delirium duration, delirium severity, and ICU and hospital length of stay. Delirium was assessed using the Confusion Assessment Method for the ICU and delirium severity using the Delirium Ratin

SUBMITTER: Khan BA 

PROVIDER: S-EPMC10924437 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature