Associations Between Buprenorphine\Naloxone and Methadone Treatment and non-Opioid Substance Use in Prescription-Type Opioid Use Disorder: Secondary Analyses From the OPTIMA Study: Associations entre le traitement avec la buprenorphine/naloxone et avec la methadone et l'utilisation de substances non opioides dans le trouble lie a l'usage d'opioides de type sur ordonnance : analyses secondaires de l'etude OPTIMA.

ABSTRACT:

Objectives

There is limited evidence on how opioid agonist treatment (OAT) may affect psychoactive non-opioid substance use in prescription-type opioid use disorder (POUD) and whether this effect might explain OAT outcomes. We aimed to assess the effect of methadone on non-opioid substance use compared to buprenorphine/naloxone (BUP/NX), to explore whether non-opioid substance use is associated with opioid use and retention in treatment, and to test non-opioid use as a moderator of associations between methadone with retention in OAT and opioid use compared to BUP/NX.

Methods

This is a secondary analysis of data from the OPTIMA trial, an open-label, pragmatic, parallel, two-arm, pan-Canadian, multicentre, randomized-controlled trial to compare standard methadone model of car

SUBMITTER: Bakouni H 

PROVIDER: S-EPMC10924583 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature