Δ⁹ -Tetrahydrocannabinol self-administration induces cell type-specific adaptations in the nucleus accumbens core.

ABSTRACT: Drugs of abuse induce cell type-specific adaptations in D1- and D2-medium spiny neurons (MSNs) in the nucleus accumbens core (NAcore) that can bias signalling towards D1-MSNs and enhance relapse vulnerability. Whether Δ⁹ -tetrahydrocannabinol (THC) use initiates similar neuroadaptations is unknown. D1- and D2-Cre transgenic rats were transfected with Cre-dependent reporters and trained to self-administer THC + cannabidiol (THC + CBD). After extinction training spine morphology, glutamate transmission, CB1R function and cFOS expression were quantified. We found that extinction from THC + CBD induced a loss of large spine heads in D1- but not D2-MSNs and commensurate reductions in glutamate synaptic transmission. Also, presynaptic CB1R function was impaired selectively at glutamat

SUBMITTER: Garcia-Keller C 

PROVIDER: S-EPMC10924663 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature