Regional pulmonary perfusion, blood volume, and their relationship change in experimental early ARDS.

ABSTRACT: Regional pulmonary perfusion (Q) has been investigated using blood volume (F_b) imaging as an easier-to-measure surrogate. However, it is unclear if changing pulmonary conditions could affect their relationship. We hypothesized that vascular changes in early acute respiratory distress syndrome (ARDS) affect Q and F_b differently. Five sheep were anesthetized and received lung protective mechanical ventilation for 20 h while endotoxin was continuously infused. Using dynamic ¹⁸F-FDG and ¹³NN Positron Emission Tomography (PET), regional F_b and Q were analysed in 30 regions of interest (ROIs) and normalized by tissue content (F_bn and Q_n, respectively). After 20 h, the lung injury showed characteristics of early ARDS, in

SUBMITTER: Santos A 

PROVIDER: S-EPMC10925058 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature