Individualized temporal patterns dominate cortical upstate and sleep depth in driving human sleep spindle timing.

ABSTRACT: Sleep spindles are critical for memory consolidation and strongly linked to neurological disease and aging. Despite their significance, the relative influences of factors like sleep depth, cortical up/down states, and spindle temporal patterns on individual spindle production remain poorly understood. Moreover, spindle temporal patterns are typically ignored in favor of an average spindle rate. Here, we analyze spindle dynamics in 1008 participants from the Multi-Ethnic Study of Atherosclerosis using a point process framework. Results reveal fingerprint-like temporal patterns, characterized by a refractory period followed by a period of increased spindle activity, which are highly individualized yet consistent night-to-night. We observe increased timing variability with age and distinct ge

SUBMITTER: Chen S 

PROVIDER: S-EPMC10925076 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature