The transcriptional response of cortical neurons to concussion reveals divergent fates after injury.

ABSTRACT: Traumatic brain injury (TBI) is a risk factor for neurodegeneration, however little is known about how different neuron types respond to this kind of injury. In this study, we follow neuronal populations over several months after a single mild TBI (mTBI) to assess long ranging consequences of injury at the level of single, transcriptionally defined neuronal classes. We find that the stress responsive Activating Transcription Factor 3 (ATF3) defines a population of cortical neurons after mTBI. We show that neurons that activate ATF3 upregulate stress-related genes while repressing many genes, including commonly used markers for these cell types. Using an inducible reporter linked to ATF3, we genetically mark damaged cells to track them over time. Notably, we find that a population in layer

SUBMITTER: Alkaslasi MR 

PROVIDER: S-EPMC10925231 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature