O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis.

ABSTRACT: Gene transcription is a highly regulated process, and deregulation of transcription factors activity underlies numerous pathologies including cancer. Albeit near four decades of studies have established that the E2F pathway is a core transcriptional network that govern cell division in multi-cellular organisms^1,2, the molecular mechanisms that underlie the functions of E2F transcription factors remain incompletely understood. FOXK1 and FOXK2 transcription factors have recently emerged as important regulators of cell metabolism, autophagy and cell differentiation^3-6. While both FOXK1 and FOXK2 interact with the histone H2AK119ub deubiquitinase BAP1 and possess many overlapping functions in normal biology, their specific functions as well as deregulation of their transc

SUBMITTER: Masclef L 

PROVIDER: S-EPMC10925292 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature