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An Anatomical and Physiological Basis for Coincidence Detection Across Time Scales in the Auditory System.

ABSTRACT: Coincidence detection is a common neural computation that identifies co-occurring stimuli by integration of inputs. In the auditory system, octopus cells act as coincidence detectors for complex sounds that include both synchronous and sequenced combinations of frequencies. Octopus cells must detect coincidence on both the millisecond and submillisecond time scale, unlike the average neuron, which integrates inputs over time on the order of tens of milliseconds. Here, we show that octopus cell computations in the cell body are shaped by inhibition in the dendrites, which adjusts the strength and timing of incoming signals to achieve submillisecond acuity. This mechanism is crucial for the fundamental process of integrating the synchronized frequencies of natural auditory signals over time.

SUBMITTER: Kreeger LJ

PROVIDER: S-EPMC10925315 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System.

Kreeger Lauren J LJ Honnuraiah Suraj S Maeker Sydney S Shea Siobhan S Fishell Gord G Goodrich Lisa V LV

bioRxiv : the preprint server for biology 20241121

Animals navigate the auditory world by recognizing complex sounds, from the rustle of a predator to the call of a potential mate. This ability depends in part on the octopus cells of the auditory brainstem, which respond to multiple frequencies that change over time, as occurs in natural stimuli. Unlike the average neuron, which integrates inputs over time on the order of tens of milliseconds, octopus cells must detect momentary coincidence of excitatory inputs from the cochlea during an ongoing ...[more]

PMID: 38464181

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