PTM-Mamba: A PTM-Aware Protein Language Model with Bidirectional Gated Mamba Blocks.

ABSTRACT: Proteins serve as the workhorses of living organisms, orchestrating a wide array of vital functions. Post-translational modifications (PTMs) of their amino acids greatly influence the structural and functional diversity of different protein types and uphold proteostasis, allowing cells to swiftly respond to environmental changes and intricately regulate complex biological processes. To this point, efforts to model the complex features of proteins have involved the training of large and expressive protein language models (pLMs) such as ESM-2 and ProtT5, which accurately encode structural, functional, and physicochemical properties of input protein sequences. However, the over 200 million sequences that these pLMs were trained on merely scratch the surface of proteomic diversity, as they nei

SUBMITTER: Peng Z 

PROVIDER: S-EPMC10925343 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature