Ontology highlight
ABSTRACT:
SUBMITTER: Barrero DJ
PROVIDER: S-EPMC10925344 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Barrero Daniel J DJ Wijeratne Sithara S SS Zhao Xiaowei X Cunningham Grace F GF Rui Yan Y Nelson Christian R CR Yasuhiro Arimura A Funabiki Hironori H Asbury Charles L CL Yu Zhiheng Z Subramanian Radhika R Biggins Sue S
bioRxiv : the preprint server for biology 20240229
Eukaryotic chromosome segregation requires kinetochores, multi-megadalton protein machines that assemble on the centromeres of chromosomes and mediate attachments to dynamic spindle microtubules. Kinetochores are built from numerous complexes, and understanding how they are arranged is key to understanding how kinetochores perform their multiple functions. However, an integrated understanding of kinetochore architecture has not yet been established. To address this, we purified functional, nativ ...[more]