Investigating brain dynamics and their association with cognitive control in opioid use disorder using naturalistic and drug cue paradigms.

ABSTRACT:

Objectives

Opioid use disorder (OUD) impacts millions of people worldwide. The prevalence and debilitating effects of OUD present a pressing need to understand its neural mechanisms to provide more targeted interventions. Prior studies have linked altered functioning in large-scale brain networks with clinical symptoms and outcomes in OUD. However, these investigations often do not consider how brain responses change over time. Time-varying brain network engagement can convey clinically relevant information not captured by static brain measures.

Methods

We investigated brain dynamic alterations in individuals with OUD by applying a new multivariate computational framework to movie-watching (i.e., naturalistic; N=76) and task-based (N=70) fMRI. We further probed the associati

SUBMITTER: Ye J 

PROVIDER: S-EPMC10925365 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature