Comparative analysis of swine leukocyte antigen gene diversity in Gottingen Minipigs.

ABSTRACT: Worldwide, pigs represent economically important farm animals, also representing a preferred preclinical large animal model for biomedical studies. The need for swine leukocyte antigen (SLA) typing is increasing with the expanded use of pigs in translational research, infection studies, and for veterinary vaccine design. Göttingen Minipigs (GMP) attract increasing attention as valuable model for pharmacological studies and transplantation research. This study represents a first-time assessment of the SLA gene diversity in Göttingen Minipigs in combination with a comparative metadata analysis with commercial pig lines. As Göttingen Minipigs could harbor private as well as potential novel SLA allele combinations, future research projects would benefit from the characterization of their SLA b

SUBMITTER: Hammer SE 

PROVIDER: S-EPMC10925748 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature