Association of maternal insulin resistance with neonatal insulin resistance and body composition/size: a prospective cohort study in a sub-Saharan African population.

ABSTRACT:

Purpose

We prospectively evaluated the association of the insulin resistance of third-trimester Nigerian pregnant women with their newborn infants' insulin resistance and birth size. Pregnancy-associated insulin resistance (IR), often assessed with homeostatic model assessment of IR (HOMA-IR), is associated, especially among women with gestational diabetes (GDM), with abnormal neonatal birth size and body composition, predisposing the baby to metabolic disorders like diabetes and obesity. The associations of maternal IR with neonatal IR, birth size and body composition are less studied in nondiabetic pregnant women, especially in sub-Saharan settings like Nigeria.

Methods

We originally recruited 401 third trimester, nondiabetic pregnant women to a prospective cohort study, f

SUBMITTER: Akinola IJ 

PROVIDER: S-EPMC10925788 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature