Association between nitric oxide synthase 3 genetic variant and acute kidney injury following pediatric cardiac surgery.

ABSTRACT:

Background

Acute kidney injury (AKI) complicates 30% to 50% of cardiac surgeries in pediatric patients. Genetic variants that affect renal blood flow and inflammation have been associated with AKI after cardiac surgery in diverse populations of adults but have not been studied in children. The objective of this study is to test the hypothesis that common candidate genetic variants are associated with AKI following pediatric cardiac surgery.

Methods

This is a retrospective cohort study at a single tertiary referral children's hospital of 2,062 individual patients undergoing surgery for congenital heart disease from September 2007 to July 2020. Pre-specified variants in candidate genes (AGTR1, APOE, IL6, NOS3, and TNF) were chosen. AKI was defined using Kidney Disease: Improvi

SUBMITTER: Kikano S 

PROVIDER: S-EPMC10925835 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature