Evaluating infusion methods and simplified quantification of synaptic density in vivo with [¹¹C]UCB-J and [¹⁸F]SynVesT-1 PET.

ABSTRACT: For some positron emission tomography studies, radiotracer is administered as bolus plus continuous infusion (B/I) to achieve a state of equilibrium. This approach can reduce scanning time and simplify data analysis; however, the method must be validated and optimized for each tracer. This study aimed to validate a B/I method for in vivo quantification of synaptic density using radiotracers which target the synaptic vesicle glycoprotein 2 A: [¹¹C]UCB-J and [¹⁸F]SynVesT-1. Observed mean standardized uptake values (SUV) in target tissue relative to that in plasma (C_T/C_P) or a reference tissue (SUVR-1) were calculated for 30-minute intervals across 120 or 150-minute dynamic scans and compared against one-tissue compartment (1TC)

SUBMITTER: Asch RH 

PROVIDER: S-EPMC10925870 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature