Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function.

ABSTRACT:

Background

Unresolved surgical inflammation might induce chronic cognitive decline in older adults. Although inflammatory biomarkers have been correlated with perioperative cognitive impairment and delirium, the effects of prolonged inflammation on cognition are not well studied. This prospective cohort study investigated 1-yr dynamics in plasma interleukin-6 levels and executive function.

Methods

Patients undergoing major surgery (n=170) aged ≥65 yr completed Trail Making Test B and other neuropsychological assessments with plasma interleukin-6 levels collected on postoperative days 1-9 and 90, and at 1-yr. Mixed-effects analyses were conducted for Trail Making Test B (and other assessments), including interleukin-6 levels, time, and additional confounders (fixed effects),

SUBMITTER: Taylor J 

PROVIDER: S-EPMC10925892 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature