Serum proteomic biomarkers diagnostic of knee osteoarthritis.

ABSTRACT:

Objective

To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics.

Design

We conducted multiple reaction monitoring mass spectrometry analysis of 107 peptides in baseline sera of two cohorts: the Foundation for National Institutes of Health (NIH) (n = 596 Kellgren-Lawrence (KL) grade 1-3 knee OA participants); and the Johnston County Osteoarthritis Project (n = 127 multi-joint controls free of radiographic OA of the hands, hips, knees (bilateral KL=0), and spine). Data were split into (70%) training and (30%) testing sets. Diagnostic peptide and clinical data predictors were selected by random forest (RF); selection was based on association (p < 0.05) with OA status in multivariable logistic regression models. Model perfo

SUBMITTER: Kraus VB 

PROVIDER: S-EPMC10925913 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature