Oncopig bladder cancer cells recapitulate human bladder cancer treatment responses in vitro.

ABSTRACT:

Introduction

Bladder cancer is a common neoplasia of the urinary tract that holds the highest cost of lifelong treatment per patient, highlighting the need for a continuous search for new therapies for the disease. Current bladder cancer models are either imperfect in their ability to translate results to clinical practice (mouse models), or rare and not inducible (canine models). Swine models are an attractive alternative to model the disease due to their similarities with humans on several levels. The Oncopig Cancer Model has been shown to develop tumors that closely resemble human tumors. However, urothelial carcinoma has not yet been studied in this platform.

Methods

We aimed to develop novel Oncopig bladder cancer cell line (BCCL) and investigate whether these urothelia

SUBMITTER: Segatto NV 

PROVIDER: S-EPMC10926022 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature