Longitudinal immune kinetics of COVID-19 booster versus primary series vaccination: Insight into the annual vaccination strategy.

ABSTRACT:

Background

Data on the durability of booster dose immunity of COVID-19 vaccines are relatively limited.

Methods

Immunogenicity was evaluated for up to 9-12 months after the third dose of vaccination in 94 healthy adults.

Results

Following the third dose, the anti-spike immunoglobulin G (IgG) antibody response against the wild-type was boosted markedly, which decreased gradually over time. However, even 9-12 months after the booster dose, both the median and geometric mean of anti-spike IgG antibody levels were higher than those measured 4 weeks after the second dose. Breakthrough infection during the Omicron-dominant period boosted neutralizing antibody titers against Omicron sublineages (BA.1 and BA.5) and the ancestral strain. T-cell immune response was efficiently

SUBMITTER: Choi MJ 

PROVIDER: S-EPMC10926122 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature