Dataset Information
Expression and prognostic role of sphingosine 1-phosphate receptor 4 (S1PR4) as a biomarker of skin cutaneous melanoma.
Ontology highlight
ABSTRACT: Background
Skin cutaneous melanoma (SKCM) is one of the most lethal skin malignancies worldwide. Sphingosine 1-phosphate (S1P) regulates tumor cells through S1P receptors (S1PRs). Unlike S1PR1/2/3/5, whose anti-apoptotic effects have been widely studied, the regulatory effect of S1PR4 on tumors has not been studied extensively. In this study, we aimed to investigate the correlation between S1PR4 expression and survival, clinical manifestations, tumor microenvironment, and immune infiltration in patients with SKCM.Results
Low S1PR4 expression was associated with poor prognosis in patients with SKCM. Patients in the high-expression group had significantly longer disease survival and progression-free survival than those in the low-expression group.Conclusion
High S1PR4 expression was highly associated with better prognosis and milder clinical manifestations; thus, S1PR4 may be used as a prognostic marker to help physicians monitor patients with SKCM.
SUBMITTER: Wang Z
PROVIDER: S-EPMC10926139 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Publications
Expression and prognostic role of sphingosine 1-phosphate receptor 4 (S1PR4) as a biomarker of skin cutaneous melanoma.
Heliyon 20240302 5
<h4>Background</h4>Skin cutaneous melanoma (SKCM) is one of the most lethal skin malignancies worldwide. Sphingosine 1-phosphate (S1P) regulates tumor cells through S1P receptors (S1PRs). Unlike <i>S1PR1/2/3/5</i>, whose anti-apoptotic effects have been widely studied, the regulatory effect of <i>S1PR4</i> on tumors has not been studied extensively. In this study, we aimed to investigate the correlation between <i>S1PR4</i> expression and survival, clinical manifestations, tumor microenvironment ...[more]