Efficacy and safety of low-dose corticosteroids combined with leflunomide for progressive IgA nephropathy: a systematic review and meta-analysis.

ABSTRACT:

Background and objective

The effectiveness of immunosuppressive and corticosteroid treatments for Immunoglobulin A (IgA) nephropathy (IgAN) remains thoroughly evaluated. We undertook a meta-analysis to investigate the efficacy and safety of low-dose corticosteroids plus leflunomide for progressive IgA nephropathy.

Methods

Eligible studies were obtained from PubMed, Embase, and Cochrane Library databases. We also searched the references of the included studies. Our protocol followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist. Eligibility criteria were defined using a PICOS framework.

Results

Our study included three articles presenting 342 patient cases. Findings revealed that low-dose corticosteroids combined with the lef

SUBMITTER: Zhang D 

PROVIDER: S-EPMC10926645 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature