Influential upregulation of KCNE4: Propelling cancer associated fibroblasts-driven colorectal cancer progression.

ABSTRACT:

Background

Colorectal cancer (CRC) is a malignancy of remarkable heterogeneity and heightened morbidity. Cancer associated fibroblasts (CAFs) are abundant in CRC tissues and are essential for CRC growth. Here, we aimed to develop a CAF-related classifier for predicting the prognosis of CRC and identify critical pro-tumorigenic genes in CAFs.

Method

The mRNA expression and clinical information of CRC samples were sourced from two comprehensive databases, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Using a weighted gene co-expression network analysis (WGCNA) approach, CAF-related genes were identified and a CAF risk signature was developed through the application of univariate analysis and the least absolute shrinkage and selection operator (LASSO) Cox re

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10926681 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature