Whole-Genome sequencing in routine Mycobacterium bovis epidemiology - scoping the potential.

ABSTRACT: Mycobacterium bovis the main agent of bovine tuberculosis (bTB), presents as a series of spatially-localised micro-epidemics across landscapes. Classical molecular typing methods applied to these micro-epidemics, based on genotyping a few variable loci, have significantly improved our understanding of potential epidemiological links between outbreaks. However, they have limited utility owing to low resolution. Conversely, whole-genome sequencing (WGS) provides the highest resolution data available for molecular epidemiology, producing richer outbreak tracing, insights into phylogeography and epidemic evolutionary history. We illustrate these advantages by focusing on a common single lineage of M. bovis (1.140) from Northern Ireland. Specifically, we investigate the spatial su

SUBMITTER: Allen A 

PROVIDER: S-EPMC10926703 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature