Incidence of skeletal-related events in patients with Ewing sarcoma: An observational retrospective study in Japan.

ABSTRACT:

Background

Skeletal-related events (SREs), including the pathological fracture, surgical treatment or radiation of bone lesions, malignant spinal cord compression, hypercalcemia, are important considerations when managing metastatic bone tumors; however, owing to their rarity, the incidence of SREs in patients with Ewing sarcoma remains unknown.

Methods

We retrospectively reviewed the clinical data from 146 patients with Ewing sarcoma treated at a single institution from 2005 to 2019. The median age at diagnosis was 22.7 years. Fifty patients (34.2%) had metastatic disease at diagnosis. The primary outcome was the SRE-free rate among patients with Ewing sarcoma. Moreover, we identified the risk factors for SREs using univariate or multivariate analyses.

Results

During

SUBMITTER: Aiba H 

PROVIDER: S-EPMC10926881 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature