Locus coeruleus features are linked to vagus nerve stimulation response in drug-resistant epilepsy.

ABSTRACT: The locus coeruleus-norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This system is known to prevent seizure development and induce long-term plastic changes, particularly with the release of norepinephrine in the hippocampus. However, the requisites to become responder to the therapy and the mechanisms of action are still under investigation. Using MRI, we assessed the structural and functional characteristics of the locus coeruleus and microstructural properties of locus coeruleus-hippocampus white matter tracts in patients with drug-resistant epilepsy responding or not to the therapy. Twenty-three drug-resistant epileptic patients with cervical vagus nerve stimulation were recruited for this pilot study, including 13 responders or parti

SUBMITTER: Berger A 

PROVIDER: S-EPMC10926962 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature