An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia.

ABSTRACT:

Background

Chronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19⁺ CD5⁺ B cells but its origin remains debated. Mutated CLL may originate from post-germinal center B cells and unmutated CLL from CD5⁺ mature B cell precursors. Irrespective of precursor types, events initiating CLL remain unknown. The cytokines BAFF and APRIL each play a significant role in CLL cell survival and accumulation, but their involvement in disease initiation remains unclear.

Methods

We generated novel CLL models lacking BAFF or APRIL. In vivo experiments were conducted to explore the impact of BAFF or APRIL loss on leukemia initiation, progression, and dissemination. Additionally, RNA-seq and quantitative real-time PCR were performed to u

SUBMITTER: Ullah MA 

PROVIDER: S-EPMC10927009 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature