Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery.

ABSTRACT: Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges associated with CBD delivery, we employed Design of Experiments (DoE), lipid carriers, and 3D printing techniques to optimize and develop buccal film loaded with CBD-NLCs. Three-factor Box-Behnken Design was carried out to optimise the NLCs and analyse the effect of independent factors on dependent factors. The emulsification-ultrasonication technique was used to prepare the NLCs. A pressure-assisted micro-syringe printing technique was used to produce the films. The produced films were studied for physicochemi

SUBMITTER: Abdella S 

PROVIDER: S-EPMC10927780 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature