Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics.

ABSTRACT:

Introduction

During the COVID-19 Delta variant surge, the CLAIRE cross-sectional study sampled saliva from 120 hospitalized patients, 116 of whom had a positive COVID-19 PCR test. Patients received antibiotics upon admission due to possible secondary bacterial infections, with patients at risk of sepsis receiving broad-spectrum antibiotics (BSA).

Methods

The saliva samples were analyzed with shotgun DNA metagenomics and respiratory RNA virome sequencing. Medical records for the period of hospitalization were obtained for all patients. Once hospitalization outcomes were known, patients were classified based on their COVID-19 disease severity and the antibiotics they received.

Results

Our study reveals that BSA regimens differentially impacted the human salivary microbi

SUBMITTER: Buendia P 

PROVIDER: S-EPMC10927822 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature