Vascular ATGL-dependent lipolysis and the activation of cPLA₂-PGI₂ pathway protect against postprandial endothelial dysfunction.

ABSTRACT: Adipose triglyceride lipase (ATGL) is involved in lipolysis and displays a detrimental pathophysiological role in cardio-metabolic diseases. However, the organo-protective effects of ATGL-induced lipolysis were also suggested. The aim of this work was to characterize the function of lipid droplets (LDs) and ATGL-induced lipolysis in the regulation of endothelial function. ATGL-dependent LDs hydrolysis and cytosolic phospholipase A₂ (cPLA₂)-derived eicosanoids production were studied in the aorta, endothelial and smooth muscle cells exposed to exogenous oleic acid (OA) or arachidonic acid (AA). Functional effects of ATGL-dependent lipolysis and subsequent activation of cPLA₂/PGI₂ pathway were also studied in vivo in relation to postprandial endoth

SUBMITTER: Sternak M 

PROVIDER: S-EPMC10927860 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature