Medicinal Polypharmacology in the Clinic - Translating the Polypharmacolome into Therapeutic Benefit.

ABSTRACT: Drugs with multiple targets, often annotated as 'unselective', 'promiscuous', 'multitarget', or 'polypharmacological', are widely considered in both academic and industrial research as a high risk due to the likelihood of adverse effects. However, retrospective analyses have shown that particularly approved drugs bear rich polypharmacological profiles. This raises the question whether our perception of the specificity paradigm ('one drug-one target concept') is correct - and if specifically multitarget drugs should be developed instead of being rejected. These questions provoke a paradigm shift - regarding the development of polypharmacological drugs not as a 'waste of investment', but acknowledging the existence of a 'lack of investment'. This perspective provides an insight into modern d

SUBMITTER: Rafehi M 

PROVIDER: S-EPMC10927880 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature