A programmed cell death-related gene signature to predict prognosis and therapeutic responses in liver hepatocellular carcinoma.

ABSTRACT:

Background

Programmed cell death (PCD) functions critically in cancers and PCD-related genes are associated with tumor microenvironment (TME), prognosis and therapeutic responses of cancer patients. This study stratified hepatocellular carcinoma (HCC) patients and develop a prognostic model for predicting prognosis and therapeutic responses.

Methods

Consensus clustering analysis was performed to subtype HCC patients in The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) among the subtypes were filtered and subjected to the least absolute shrinkage and selection operator (LASSO) regression analysis and univariate Cox regression analysis to filter prognostic genes. A PCD-related prognostic gene signature in TCGA was constructed and validated in ICGC-

SUBMITTER: Gu X 

PROVIDER: S-EPMC10928056 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature