HSPA9 reduction exacerbates symptoms and cell death in DSS-Induced inflammatory colitis.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic inflammatory condition that is influenced by various factors, including environmental factors, immune responses, and genetic elements. Among the factors that influence IBD progression, macrophages play a significant role in generating inflammatory mediators, and an increase in the number of activated macrophages contributes to cellular damage, thereby exacerbating the overall inflammatory conditions. HSPA9, a member of the heat shock protein 70 family, plays a crucial role in regulating mitochondrial processes and responding to oxidative stress. HSPA9 deficiency disrupts mitochondrial dynamics, increasing mitochondrial fission and the production of reactive oxygen species. Based on the known functions of HSPA9, we considered the possibility tha

SUBMITTER: Jang S 

PROVIDER: S-EPMC10928168 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature