Mitochondrial metabolism sustains CD8⁺ T cell migration for an efficient infiltration into solid tumors.

ABSTRACT: The ability of CD8⁺ T cells to infiltrate solid tumors and reach cancer cells is associated with improved patient survival and responses to immunotherapy. Thus, identifying the factors controlling T cell migration in tumors is critical, so that strategies to intervene on these targets can be developed. Although interstitial motility is a highly energy-demanding process, the metabolic requirements of CD8⁺ T cells migrating in a 3D environment remain unclear. Here, we demonstrate that the tricarboxylic acid (TCA) cycle is the main metabolic pathway sustaining human CD8⁺ T cell motility in 3D collagen gels and tumor slices while glycolysis plays a more minor role. Using pharmacological and genetic approaches, we report that CD8⁺ T cell migration dep

SUBMITTER: Simula L 

PROVIDER: S-EPMC10928223 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature