Depression risk in users of different doses of levonorgestrel intrauterine systems: a nationwide prospective cohort study.

ABSTRACT:

Background

Use of the high-dose levonorgestrel-releasing intrauterine system (LNG-IUS) has been associated with increased risk of incident depression. Evidence is lacking on the influence of use of two recently marketed low-dose LNG-IUS on risk of depression. This study aims to examine associations between use of different doses of LNG-IUS and risk of depression.

Methods

We conducted a nationwide prospective cohort study involving all first-time users of an LNG-IUS among all Danish nulliparous women aged 15-34 years with no medical history of depression, major psychiatric diseases, endometriosis, heavy menstrual bleeding, polyp, myoma, dysmenorrhoea, iron supplement use, abortion, and infertility treatment.

Findings

A total of 46,565 first-time users of LNG-IUS were f

SUBMITTER: Skovlund CW 

PROVIDER: S-EPMC10928294 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature