Predicting Disability in Progressive Supranuclear Palsy Using Bedside Frontal-Lobe Signs.

ABSTRACT:

Background

Frontal lobe signs in progressive supranuclear palsy (PSP) are prevalent and occur early in the disease. Although they are recognized in clinical practice, studies are needed to systematically investigate them for an in-depth understanding of the neurological substrate and their potential prognostic implications in the disease.

Objectives

To study the predictive role of frontal lobe signs in PSP, as well as to describe their neuropsychological and anatomical correlations.

Methods

Nine recognized signs of frontal lobe dysfunction were assessed in 61 patients with PSP. Those signs able to predict PSP Rating Scale (PSPRS) score at baseline were selected, a survival analysis was performed and associations with neuropsychological tests and cortical thickness par

SUBMITTER: Ruiz-Barrio I 

PROVIDER: S-EPMC10928321 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature