Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms.

ABSTRACT: Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields, including biochemistry, medicine, physics, mathematics, and computer science. These researchers adopt various research paradigms to attack the same structure prediction problem: biochemists and physicists attempt to reveal the principles governing protein folding; mathematicians, especially statisticians, usually start from assuming a probability distribution of protein structures given a target sequence and then find the most likely structure, while computer scientists formulate protein structure prediction as an optimization problem - finding the structural conformation with the lowest energy or minimizing the difference between predicted structure and native structure

SUBMITTER: Huang B 

PROVIDER: S-EPMC10928435 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature