A unified approach to dissecting biphasic responses in cell signaling.

ABSTRACT: Biphasic responses are encountered at all levels in biological systems. At the cellular level, biphasic dose-responses are widely encountered in cell signaling and post-translational modification systems and represent safeguards against overactivation or overexpression of species. In this paper, we provide a unified theoretical synthesis of biphasic responses in cell signaling systems, by assessing signaling systems ranging from basic biochemical building blocks to canonical network structures to well-characterized exemplars on one hand, and examining different types of doses on the other. By using analytical and computational approaches applied to a range of systems across levels (described by broadly employed models), we reveal (i) design principles enabling the presence of biphasic resp

SUBMITTER: Ramesh V 

PROVIDER: S-EPMC10928513 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature