Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial.

ABSTRACT:

Background

Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32-34°C attenuates organ dysfunction and reduces mortality in ventilator-dependent patients with septic shock.

Methods

In this randomised, controlled, open-label trial, we recruited patients from ten intensive care units (ICUs) in three countries in Europe and North America. Inclusion criteria for patients with severe sepsis or septic shock were a mean arterial pressure of less than 70 mm Hg, mechanical ventilation in an ICU, age at least 50 years, predicted length of stay in the ICU at least 24 h, and recruitment into the study within 6 h of fulfilling incl

SUBMITTER: Itenov TS 

PROVIDER: S-EPMC10928558 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature