Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging.

ABSTRACT: Human life expectancy is constantly increasing and aging has become a major risk factor for many diseases, although the underlying gene regulatory mechanisms are still unclear. Using transcriptomic and chromosomal conformation capture (Hi-C) data from human skin fibroblasts from individuals across different age groups, we identified a tight coupling between the changes in co-regulation and co-localization of genes. We obtained transcription factors, cofactors, and chromatin regulators that could drive the cellular aging process by developing a time-course prize-collecting Steiner tree algorithm. In particular, by combining RNA-Seq data from different age groups and protein-protein interaction data we determined the key transcription regulators and gene regulatory changes at different life

SUBMITTER: Braunger JM 

PROVIDER: S-EPMC10928569 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature