Trioxidized cysteine in the aging proteome mimics the structural dynamics and interactome of phosphorylated serine.

ABSTRACT: Aging is the primary risk factor for the development of numerous human chronic diseases. On a molecular level, it significantly impacts the regulation of protein modifications, leading to the accumulation of degenerative protein modifications (DPMs) such as aberrant serine phosphorylation (p-Ser) and trioxidized cysteine (t-Cys) within the proteome. The altered p-Ser is linked to abnormal cell signaling, while the accumulation of t-Cys is associated with chronic diseases induced by oxidative stress. Despite this, the potential cross-effects and functional interplay between these two critical molecular factors of aging remain undisclosed. This study analyzes the aging proteome of wild-type C57BL/6NTac mice over 2 years using advanced proteomics and bioinformatics. Our objective is to provid

SUBMITTER: Sanchez Milan JA 

PROVIDER: S-EPMC10928580 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature