Combinatory glycoengineering of monoclonal antibodies and its application in cancer therapy: a narrative review.

ABSTRACT:

Background and objective

The application of immunotherapy, especially in terms of recombinant monoclonal antibodies (mAbs), is a revolution in the pharmaceutical industry field. Glycosylation plays an essential role in the structures and functions of mAbs, which must be carefully monitored and designed throughout their entire lifespan to ensure safety and efficacy. This review aimed to summarize the current status of the glycoengineering of mAbs for providing reference for the pharmaceutical industry. The application of glycoengineering of mAbs in cancer therapy will also be discussed in this article.

Methods

We searched the PubMed/MEDLINE database to identify studies published between 1970 and 2023 that investigated glycoengineering of recombinant mAbs and its applications.

SUBMITTER: Wang S 

PROVIDER: S-EPMC10928611 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature