The value of a panel of circulating microRNAs in screening prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) remains a worldwide public health problem that poses a serious threat to the health of men worldwide. Many studies have found that microRNA (miRNA) in serum has the potential to be a biomarker for cancer screening. Our study was conducted to investigate the value of serum miRNAs in PCa screening.

Methods

We selected 12 miRNAs from past studies for its association with PCa. We checked the expression levels of these miRNAs in the serum of 112 PCa patients and 112 healthy controls in a two-stage experiment. We plotted the receiver operating characteristic curve of miRNAs in the validation stage and constructed a four-miRNA panel with the highest diagnostic value using stepwise logistic regression. We also predicted the target genes with these fo

SUBMITTER: Sun C 

PROVIDER: S-EPMC10928619 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature