Synthesis, Characterization, and Digital Light Processing of a Hydrolytically Degradable Hyaluronic Acid Hydrogel.

ABSTRACT: Numerous chemical modifications of hyaluronic acid (HA) have been explored for the formation of degradable hydrogels that are suitable for a variety of biomedical applications, including biofabrication and drug delivery. Thiol-ene step-growth chemistry is of particular interest due to its lower oxygen sensitivity and ability to precisely tune mechanical properties. Here, we utilize an aqueous esterification route via reaction with carbic anhydride to synthesize norbornene-modified HA (NorHA_CA) that is amenable to thiol-ene crosslinking to form hydrolytically unstable networks. NorHA_CA is first synthesized with varying degrees of modification (∼15-100%) by adjusting the ratio of reactive carbic anhydride to HA. Thereafter, NorHA_CA is reacted with dithiol cro

SUBMITTER: Galarraga JH 

PROVIDER: S-EPMC10928645 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature