Toward Translational Impact of Low-Glucose Strategies on Red Blood Cell Storage Optimization.

ABSTRACT: Transfusion of stored red blood cells (RBCs) to patients is a critical component of human healthcare. Following purification from whole blood, RBCs are stored in one of many media known as additive solutions for up to 42 days. However, during the storage period, the RBCs undergo adverse chemical and physical changes that are often collectively known as the RBC storage lesion. Storage of RBCs in additive solutions modified to contain physiological levels of glucose, as opposed to hyperglycemic levels currently used in most cases, reduces certain markers of the storage lesion, although intermittent doses of glucose are required to maintain normoglycemic conditions. Here, we describe an electrically actuated valving system to dispense small volumes of glucose into 100 mL PVC storage bags cont

SUBMITTER: Soule LD 

PROVIDER: S-EPMC10928890 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature