Homology-dependent maternal inhibition of developmental excision of internal eliminated sequences in Paramecium tetraurelia.

ABSTRACT: Thousands of single-copy internal eliminated sequences (IESs) are excised from the germ line genome of ciliates during development of the polygenomic somatic macronucleus, following sexual events. Paramecium IESs are short, noncoding elements that frequently interrupt coding sequences. No absolutely conserved sequence element, other than flanking 5'-TA-3' direct repeats, has been identified among sequenced IESs; the mechanisms of their specific recognition and precise elimination are unknown. Previous work has revealed the existence of an epigenetic control of excision. It was shown that the presence of one IES in the vegetative macronucleus results in a specific inhibition of the excision of the same element during the development of a new macronucleus, in the following sexual generation.

SUBMITTER: Duharcourt S 

PROVIDER: S-EPMC109289 | biostudies-literature | 1998 Dec

REPOSITORIES: biostudies-literature