The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues.

ABSTRACT: Recent advancements have illuminated the critical role of RNA modifications in post-transcriptional regulation, shaping the landscape of gene expression. This review explores how tRNA modifications emerge as critical players, fine-tuning functionalities that not only maintain the fidelity of protein synthesis but also dictate gene expression and translation profiles. Highlighting their dysregulation as a common denominator in various cancers, we systematically investigate the intersection of both cytosolic and mitochondrial tRNA modifications with cancer biology. These modifications impact key processes such as cell proliferation, tumorigenesis, migration, metastasis, bioenergetics and the modulation of the tumor immune microenvironment. The recurrence of altered tRNA modification patterns

SUBMITTER: Anazco-Guenkova AM 

PROVIDER: S-EPMC10928989 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature