Longevity-associated BPIFB4 gene counteracts the inflammatory signaling.

ABSTRACT:

Background

Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so called chronic low-grade inflammation, which contributes to a faster progression of aged-related cardiovascular (CV) diseases, including frailty, neurodegeneration, gastro-intestinal diseases and disorders reflected by alterations in the composition of gut microbiota. However, successful genetic programme of long-living individuals alters the trajectory of the ageing process, by promoting an efficient immune response that can counterbalance deleterious effects of inflammation and the CV complications. This is the case of BPIFB4 gene in which, homozygosity for a four single-nucleotide polymorphism (SNP) haplotype, the Longevity-Associated Variant (LAV) co

SUBMITTER: Cattaneo M 

PROVIDER: S-EPMC10929107 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature